ADA AS MAIN BIOCHEMICAL MARKER IN PATIENTS WITH TUBERCULOUS EFFUSION

Tuberculous pleuritis (TP) is one of the most common extra-pulmonary tuberculosis form. Because tuberculous pleurisy hard to diagnose due slow course disease and lack specificity in symptoms diagnostic methods. In that reason, we need multidisciplinary approach efficient biomarkers. Acid-fast bacilli (AFB) staining, cultures pathophysiological biopsy finding from majority patients are positive only less than 10%. Löwenstein culture results time about 6-8 weeks what delays diagnosis. Adenosine deaminase (ADA) biomarker with high sensitivity (more 90%) considered as gold standard biomarkers diagnosis TP. It very distinguish malignant TP lymphocyte predomination, but patient pleural effusion level ADA decreased, opposite punctate a fast, simple, economical way for clarification etiology pleurisy. Also, many studies have proved role response treatment at follow up period